Fri May 20 2022

26 articles - From Friday May 13 2022 to Friday May 20 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Nephrol Dial Transplant

Transitional care models in adolescent kidney transplant recipients - a systematic review.

Despite the well-established need for good transitional care in paediatric solid-organ transplant recipients, models tailored specifically for kidney transplant recipients are lacking. Further research and validation studies are required, to ascertain the most best method of providing effective transitional care to these patients. Transitional care should become a standardised process for adolescents and young adults with a kidney transplant.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Kidney Dis

Performance of the 2021 Race-Free CKD-EPI Creatinine- and Cystatin C-Based Estimated GFR Equations Among Kidney Transplant Recipients.

Few patients with a GFR <30 mL/min/1.73 m2 and the large majority of patients were White. Among kidney transplant recipients the new 2021 race-free CKD-EPI eGFR equations perform similarly to the prior CKD-EPI equations which included race correction terms. No significant difference in performance was observed between the 2021 CKD-EPICr and 2021 CKD-EPICr/CysC equations in the kidney transplant population.

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Clin J Am Soc Nephrol

Apolipoprotein L1 High-Risk Genotypes and Albuminuria in Sub-Saharan African Populations.

Background and objectives Recessive inheritance of African-specific risk variants were associated with albuminuria but not eGFR <60 ml/min per 1.73 m 2 . There may be differential effects of homozygous G1 and G2 genotypes on albuminuria that require further investigation. Podcast This article contains a podcast at

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Glomerular Exostosin as a Subtype and Activity Marker of Class V Lupus Nephritis.

exostosin positivity occured frequently in patients with class V lupus nephritis, and the exostosin-positive cases have more severe proteinuria and a lower rate of histologic transition than the exostosin-negative patients.

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Low-Flow Acute Kidney Injury: The Pathophysiology of Prerenal Azotemia, Abdominal Compartment Syndrome, and Obstructive Uropathy.

In al three cases, with early recognition and correction of the underlying process, the resulting functional AKI can be rapidly reversed. However, with continued duration and/or increased severity, cell injury occurs within the kidney, resulting in structural AKI and a longer and more severe disease state with increased morbidity and mortality. This is why early recognition and reversal are critical.

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Medicare Bundled Payment Policy on Anemia Care, Major Adverse Cardiovascular Events, and Mortality among Adults Undergoing Hemodialysis.

Acute myocardial infarction risk (adjusted hazard ratio, 1.04; 95% confidence interval, 1.01 to 1.06) was higher after policies changed. The Medicare reimbursement policy and Food and Drug Administration-recommended erythropoietin-stimulating agent dosing changes were associated with lower erythropoietin-stimulating agent use and lower hemoglobin levels. These changes in anemia care were associated with lower risks of major adverse cardiovascular event, stroke, mortality, and heart failure but higher risk of acute myocardial infarction among adults receiving hemodialysis.

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Sepsis Management for the Nephrologist.

A nuanced understanding of the physiology of lactate is provided in our review. Physiologic and practical knowledge of steroid and vasopressor therapy for sepsis is crucial and addressed. As blood purification may interest the nephrologist treating sepsis, we have also added a brief discussion of its status.

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J Am Soc Nephrol

Arginase-1 Is Required for Macrophage-Mediated Renal Tubule Regeneration.

GM-CSF-induced, proreparative macrophages express arginase-1, which is required for the S3 tubular cell proliferative response that promotes renal repair after ischemia-reperfusion injury.

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Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells.

These results suggest that, in addition to CaSR's established role in the parathyroid-kidney-bone axis, expression of CaSR in vascular smooth muscle cells directly contributes to total body mineral ion homeostasis.

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Kidney Biopsy Features Most Predictive of Clinical Outcomes in the Spectrum of Minimal Change Disease and Focal Segmental Glomerulosclerosis.

The most predictive descriptors of clinical outcomes among MCD/FSGS patients reflected structural changes in multiple renal compartments. Reporting these descriptors should be standardized to guide prognostication of proteinuric glomerular diseases.

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Nephrol Dial Transplant

Adrenal insufficiency is common amongst kidney transplant recipients receiving maintenance prednisolone and can be predicted using morning cortisol.

Our results suggest KTR are at higher risk for AI than previously reported. A morning serum cortisol measurement is a useful screening tool in this cohort, reducing the need for stimulatory testing by 44%. KTR with AI need education regarding glucocorticoid sick rules similar to patients with other forms of AI.

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Association of serum potassium with decline in residual kidney function in incident hemodialysis patients.

In conclusion, hyperkalemia is associated with decline in residual kidney function amongst incident HD patients. These findings may have important clinical implications in the management of hyperkalemia in advanced CKD if confirmed in additional studies including clinical trials.

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End-proximal tubule phosphate concentration increases as GFR falls in humans: measurement by means of a lithium clearance-based methodology.

ePTpc progressively increases in humans as functional renal mass falls independently from plasma P levels. Main determinants of ePTpc rise are GFR fall, degree of phosphaturia per unit GFR, and P intake corrected for GFR. It may become a novel, potentially useful, indicator to guide management of CKD patients.

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Possible role for rare TRPM7 variants in patients with hypomagnesemia with secondary hypocalcemia.

We establish TRPM7 as a prime candidate gene for autosomal dominant hypomagnesemia and secondary hypocalcemia. Screening of unresolved patients with hypomagnesemia and secondary hypocalcemia may further establish TRPM7 pathogenic variants as a novel Mendelian disorder.

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The risks associated with percutaneous native kidney biopsies: a prospective study.

The risk factors for major complications were higher plasma creatinine levels (OR 1.12 for each mg/dL increase, 95% CI 1.08-1.17), liver disease (OR 2.27, CI 1.21-4.25), and a higher number of needle passes (OR for each pass 1.22, CI 1.07-1.39), whereas higher proteinuria levels (OR for each g/day increase 0.95, CI 0.92-0.99) were protective. This is the first multicentre prospective study showing that percutaneous native kidney biopsies are associated with a 5% risk of a major post-biopsy complication. Predictors of increased risk include higher plasma creatinine levels, liver disease, and a higher number of needle passes.

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Usefulness of urinary biomarkers to estimate the interstitial fibrosis surface in diabetic nephropathy with normal kidney function.

our study provides a model to estimate the IF in DN that can be useful to assess the progression of IF in patients with normal kidney function.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

J Am Soc Nephrol

Molecular Characterization of Membranous Nephropathy: Quo Vadis?

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More than a Marker: Arginase-1 in Kidney Repair.

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Nephrol Dial Transplant

The chronology of the clinical cardio renal links and health outcomes.

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Letters&Replies

Letters to the editors and authors’ replies

Am J Kidney Dis

Dialysis Prevalence in Zimbabwe: A Cross-Sectional Descriptive Study.

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Clin J Am Soc Nephrol

Humoral Response to Third Dose of SARS-CoV-2 Vaccines in the CKD Spectrum.

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Kidney Int

Inferior cellular and humoral immunity against Omicron and Delta VOC compared to SARS-CoV-2 wild-type in hemodialysis patients immunized with four SARS-CoV-2 vaccine doses.

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Others

all remaining publications eg case reports, images of the month, etc…

Clin J Am Soc Nephrol

Chlorthalidone and Advanced Chronic Kidney Disease.

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Medicare Bundled Payment Policy and Anemia Care: Perspectives from a Patient with Kidney Disease.

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Statement of Clarification: Chronic Kidney Disease from Polyvinylpyrrolidone Deposition in Persons with Intravenous Drug Use.

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Nephrol Dial Transplant

Peer-reviewing and medical publication.

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